Which treatment is commonly used for pemphigus vulgaris?

Pemphigus vulgaris is an autoimmune blistering disorder characterized by the presence of antibodies against desmogleins, which are components of the desmosomes in the skin. The mainstay of treatment involves managing inflammation and autoimmunity, where oral and topical steroids play a crucial role.

Oral steroids, such as prednisone, are commonly used at high doses initially to control disease activity and reduce blister formation. Topical steroids may also be applied to localized lesions to help with inflammation and promote healing. This combination helps to suppress the immune response that causes the blistering in pemphigus vulgaris, addressing both the symptoms and the underlying pathology.

Additionally, while immunosuppressants can be utilized in more severe or resistant cases of pemphigus vulgaris, the immediate approach primarily involves the use of steroids to effectively manage acute symptoms and control disease activity. Therefore, using oral and topical steroids as a foundational therapy is essential in the treatment regimen for pemphigus vulgaris.