Which of these is NOT a classic triad of findings for trisomy 18?

In the context of trisomy 18, also known as Edwards syndrome, the classic triad of findings includes oligohydramnios, rocker bottom feet, and clenched hands. Each of these findings is associated with the characteristic abnormalities seen in this chromosomal condition.

Oligohydramnios refers to a decreased amount of amniotic fluid and is commonly observed in pregnancies affected by trisomy 18 due to associated renal anomalies and decreased fetal urine output. Rocker bottom feet are a distinctive physical feature characterized by a convex shape of the feet, which is a significant indicator of this condition. Clenched hands exhibit a specific posture that is often noted in infants with trisomy 18, reflecting the neurological and musculoskeletal abnormalities present in this syndrome.

In contrast, elevated maternal serum alpha-fetoprotein (MsAFP) is not typically a classic finding in trisomy 18. While abnormalities in MsAFP levels can indicate various genetic conditions, it is most commonly associated with neural tube defects or other conditions leading to increased fetal protein in the maternal blood. In the case of trisomy 18, the levels are often normal or within expected ranges rather than elevated. Hence, elevated MsAFP does not belong to the classic triad of findings