What is the risk of meningitis due to GBS sepsis in neonates?

Group B Streptococcus (GBS) is a significant pathogen in neonates, commonly associated with early-onset sepsis and meningitis. The risk of developing meningitis as a complication of GBS sepsis in the neonatal population is estimated to be around 1%. This relatively low risk is important for clinicians to understand, as it influences decisions surrounding screening and prophylactic measures during pregnancy, particularly in relation to intrapartum antibiotic prophylaxis for GBS colonization.

While the other percentages may seem plausible, they do not accurately reflect the current understanding of GBS meningitis risk. Studies and clinical guidelines emphasize that, although GBS can lead to serious infections, the incidence of meningitis specifically following GBS sepsis remains lower than the higher percentages suggested in the other options. This clear delineation aids medical professionals in managing both expectant care during labor and potential interventions for neonates at risk, ensuring judicious use of resources while still prioritizing patient safety.