What is the recommended progesterone supplementation regimen until 10 weeks in early pregnancy?

The recommended regimen of progesterone supplementation until 10 weeks in early pregnancy typically involves taking 200 to 300 mg orally on a daily basis. This dosage is based on evidence supporting the use of oral progesterone for the maintenance of early pregnancy, particularly in women who may be at risk for miscarriage due to low progesterone levels.

Progesterone plays a crucial role in preparing the endometrium for a potential implantation of the embryo and maintaining a supportive environment for early pregnancy. When given in adequate doses, it helps to stabilize the uterine lining, reduces the risk of pregnancy loss, and supports the development of the fetus during this critical period.

Other routes of administration, such as intramuscular, vaginal, or subcutaneous, may be utilized based on specific clinical situations or patient preferences, but the oral route of 200-300 mg daily is widely recognized as a standard approach in many guidelines. The effectiveness and convenience of oral supplementation make it a favored option in clinical practice for early pregnancy support.