What is the delivery timing recommendation for complicated FGR characterized by absent end-diastolic flow (AEDF)?

The recommendation for delivery timing in cases of complicated fetal growth restriction (FGR) characterized by absent end-diastolic flow (AEDF) is typically between 30-32 weeks. This is largely due to the significant risk associated with AEDF, which indicates a compromised placental blood flow and a higher likelihood of adverse outcomes such as stillbirth or neonatal morbidity.

In these scenarios, early delivery is prioritized to mitigate the risks associated with prolonged exposure to a compromised uterine environment. The 30-32 week range aligns with clinical guidelines that suggest intervention when there is evidence of severe compromise, as AEDF is indicative of an unfavorable fetal status. Monitoring has shown that fetal health can deteriorate rapidly at this stage, making timely delivery crucial for improving neonatal outcomes.

While other timing options may be considered for less complicated FGR cases, the presence of AEDF necessitates a more urgent intervention to safeguard the health of the fetus. Therefore, the correct choice reflects the urgent nature of this situation, aligning with established clinical practice guidelines.