What is one of the diagnostic criteria for early pregnancy loss?

The correct diagnostic criterion for early pregnancy loss is a mean sac diameter of 25mm with no embryo. This measurement is critical because an empty gestational sac at this size indicates that the pregnancy is not progressing normally. At this point in development, if there is no visible embryonic tissue within the gestational sac, it generally suggests that the pregnancy has ceased to develop and is not viable.

In the context of early pregnancy loss, other assessments may indicate problems, but the specific measurement of the mean sac diameter reaching 25mm without an embryo is a well-established benchmark that points towards a diagnosis of anembryonic pregnancy—also known as a blighted ovum. This finding is consistent across obstetric practices and aligns with established criteria used in clinical practice for diagnosing miscarriage.

Other criteria mentioned can be indicative of potential issues in early pregnancy; however, they do not provide as clear a diagnosis of early pregnancy loss as the measurement of the mean sac diameter. For instance, the presence of an embryo without a heartbeat after 6 weeks might still leave room for further assessment, as some pregnancies may not display a heartbeat until later. Similarly, the criterion of CRL greater than 10mm without a heartbeat can also imply a possible early pregnancy loss,