In Lynch syndrome, endometrial biopsies should be conducted starting at what age?

In Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), individuals have an increased risk for several types of cancers, including endometrial cancer. According to clinical guidelines, screening for endometrial cancer should begin at age 30 for women with Lynch syndrome. This recommendation is grounded in evidence that indicates the risk of endometrial cancer significantly increases after this age.

Starting screening at age 30 allows for earlier detection of potential malignancies, which can be critical for management and treatment options. While some guidelines suggest that other screening measures, such as colonoscopies, may start even earlier, the specific initiation of endometrial biopsy screening is recommended at this age to balance the risks and benefits of earlier intervention with the expected age of onset for related cancers.